Table 1.

Key parameters and measurements: baseline is 2-4 weeks before surgery, (hospital) admission is 1-3 days before surgery, (hospital) discharge is 1 week after surgery, and postoperative is 2 weeks after surgery.

Variables		Participants	Measurements	Baseline	Admission	Discharge	Postoperative
Primary outcomes
	Self-reported stress	Patients and caregivers	VASa,stress	Yes	Yes	Yes	Yes
	Self-reported pain	Patients	VASpain	Yes	Yes	Yes	Yes
	Anxiety and depression	Patients	HADSb	Yes	Yes	Yes	Yes
Secondary outcomes
	HRQoLc	Patients	EQ-5D-3L	Yes	Yes	Yes	No
	Emotional status	Patients	PANASd	Yes	Yes	Yes	Yes
	Mental well-being	Patients and caregivers	SWEMWBSe	Yes	No	No	Yes
	Self-efficacy	Patients and caregivers	GSE-SFf	Yes	No	No	Yes
	Activation status	Patients	PAM-13g	Yes	Yes	No	Yes
Usability outcomes
	CARINAE’s usability	Intervention group patients, HCPsh and caregivers	SUSi	No	Yes	Yes	Yes
	Recommendation grade for CARINAE	Intervention group patients, HCPs and caregivers	NPSj	No	Yes	Yes	Yes
	General satisfaction with CARINAE	Intervention group patients, HCPs and caregivers	Ad hoc	No	Yes	Yes	Yes
Covariates
	Demographics	Patients	Self-report assessment questionnaire	Yes	No	No	No
	Clinical data	HCPs	HCP report	Yes	Yes	Yes	Yes
	Length of hospital stay	Patients	HCP report	No	Yes	Yes	No

^aVAS: visual analogue scale.

^bHADS: Hospital Anxiety and Depression Scale.

^cHRQoL: health-related quality of life.

^dPANAS: Positive and Negative Affect Schedule.

^eSWEMWBS: Short Warwick Edinburgh Mental Well-Being Scale.

^fGSE-SF: General Self-Efficacy-Short Form.

^gPAM-13: Patient Activation Measure short form.

^hHCP: health care professional.

ⁱSUS: Stem Usability Scale.

^jNPS: Net Promoter Score.