Table 1.
Characteristics of GC patient including for classification modeling.
| Characteristics | Training cohort (n=526) | Internal validation cohort (n=132) | P-value | External validation cohort (n=93) | P-value |
|---|---|---|---|---|---|
| Age, mean ± SD, year | 61.33 ± 11.30 | 60.27 ± 10.81 | 0.333 | 67.26 ± 9.54 | <0.001 |
| Tumor size, mean ± Std, mm | 37.94 ± 22.86 | 41.00 ± 25.08 | 0.178 | 40.55 ± 27.09 | 0.325 |
| Gender, No.(%) | 0.047 | <0.001 | |||
| Male | 313 (59.51) | 91 (68.94) | 74 (79.57) | ||
| Female | 213 (40.49) | 41 (31.06) | 19 (80.43) | ||
| Tumor location, No.(%) | 0.316 | 0.004 | |||
| Upper-third | 93 (17.68) | 27 (20.46) | 27 (29.03) | ||
| Middle-third | 158 (30.04) | 31 (23.48) | 15 (16.13) | ||
| Lower-third | 275 (52.28) | 74 (56.06) | 51 (54.84) | ||
| Pathological T stage † , No.(%) | 0.962 | 0.005 | |||
| T1 | 210 (39.92) | 53 (40.15) | 23 (24.73) | ||
| T2-4 | 316 (60.08) | 79 (59.85) | 70 (75.27) | ||
| Lauren’s classification, No.(%) | 0.074 | 0.006 | |||
| Intestinal type | 301 (57.22) | 69 (52.27) | 37 (39.78) | ||
| Diffuse type | 97 (18.44) | 36 (27.27) | 27 (29.04) | ||
| Mixed type | 128 (24.34) | 27 (20.46) | 29 (31.18) | ||
| Grade of differentiation, No.(%) | 0.604 | 0.437 | |||
| Poor/undifferentiated | 206 (39.16) | 58 (43.94) | 43 (46.24) | ||
| Moderate | 280 (53.23) | 65 (49.24) | 44 (47.31) | ||
| Well | 40 (7.61) | 9 (6.82) | 6 (6.45) | ||
| CEA level, No.(%) | 0.067 | 0.518 | |||
| Negative | 488 (92.78) | 116 (87.88) | 88 (94.62) | ||
| Positive | 38 (7.22) | 16 (12.12) | 5 (5.38) | ||
| CA12-5 level, No.(%) | 0.853 | 0.382 | |||
| Negative | 504 (95.82) | 126 (95.45) | 88 (94.62) | ||
| Positive | 22 (4.18) | 6 (4.55) | 5 (5.38) | ||
| CA19-9 level, No.(%) | 0.342 | 0.004 | |||
| Negative | 445 (84.60) | 116 (87.88) | 89 (95.70) | ||
| Positive | 81 (15.40) | 16 (12.12) | 4 (4.30) |
Quantitative variables were in mean ± SD and qualitative variables are in n (%). †According to the eighth edition AJCC Cancer Staging Manual. Bold values meant P-value < 0.05.