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. Author manuscript; available in PMC: 2022 Dec 14.
Published in final edited form as: Int J Pharm. 2022 Aug 3;625:122072. doi: 10.1016/j.ijpharm.2022.122072

Fig. 4.

Fig. 4.

(a and b) LCMS spectra for LND (Rt:17.07 min) and ISD (Rt: 7.79 min). (c and d) Corresponding mass spectra for LND ((M + H)+ 321.02 m/z) and 1-benzyl imidazolyl-3-carboxylic acid ((M + H)+ 253.09 (m/z)). (e and f) LOD and LOQ extracted ion chromatogram (XIC) spectra overlay for LND. Corresponding ISD spectra overlay was also provided. Data clearly shows no interference from the matrix background. (g) XIC overlay for the blank tissue and 500 ng/mL drug spiked tissue extracted in ACN show consistent recovery for all the samples.