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. 2022 Dec 14;23(1):159. doi: 10.1186/s10194-022-01526-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Main effect of painful heat applied to the left forearm at baseline (i.e. pre-treatment). A) immediate BOLD response to painful stimulation (measured starting with the MRI frame during which the painful heat stimulus began and ending 12.5 s later). B) delayed BOLD response to painful stimulation (measured starting 12.5 s after onset of painful heat stimulus and ending 12.5 s later). Hotter colors represent stronger activation