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. 2022 Dec 12;8(2):e002412. doi: 10.1136/rmdopen-2022-002412

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Study design. A total of 223 patients in the RA MTX cohort, 323 in the RA non-MTX cohort and 1690 in the non-RA cohort achieve pregnancy during the follow-up period. The proportion of days covered by MTX treatment was calculated by dividing the milligrams of active substance purchased by the subject by the defined daily dose (DDD) and then by the follow-up period before pregnancy. MTX, methotrexate; RA, rheumatoid arthritis; PDC, proportion of days covered.