Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 13;10(12):e005088. doi: 10.1136/jitc-2022-005088

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

High levels of SP140 in the pan-cancer TCGA tumors are associated with IFN-γ-dominant tumors and high infiltration of proinflammatory TAMs (M1) and CD8 T cells. (A) Association of SP140 gene expression with immune infiltrate subtypes in the TCGA pan-cancer cohort (n=12 839). (B, C) TCGA pan-cancer gene expression data were used to dichotomize SP140 expression based on the median. M1 macrophage and T-cell infiltrations were estimated for each cancer type in SP140 high and SP140 low tumors. Data are presented as scatter plots. The statistical significance is annotated by the number of stars. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. IFN-γ, interferon gamma; M1, proinflammatory phenotype; SP140, speckled protein 140; TAM, tumor-associated macrophage; TCGA, The Cancer Genome Atlas.