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. 2022 Dec 13;10(12):e005088. doi: 10.1136/jitc-2022-005088

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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(A, B) Correlation of SP140 expression with M1 macrophage and CD8 T-cell infiltration levels HNSCC (n=497). (C, D) Genes whose expression significantly correlated with SP140 expression were analyzed by GSEA in HNSCC samples (n = 522). The plot shows the top positively enriched pathways, hallmark inflammatory response, IFN-γ response, and T-cell activation. The Y-axis is the GSEA enrichment score. The X-axis is a list of genes ranked by differential expression correlation with SP140, with black bars representing genes in each gene set. GSEA, gene set enrichment analysis; HNSCC, head and neck squamous cell carcinoma; IFN-γ, interferon gamma; M1, proinflammatory phenotype; SP140, speckled protein 140.