Table 1.
Baseline anthropometric, obstetric, and bleeding characteristics, by group. CD, Caesarean delivery; IQR, inter-quartile range; PPH, postpartum haemorrhage; TXA, tranexamic acid. Values are quoted as the mean (standard deviation), unless otherwise indicated. T0, at inclusion (baseline); T1, at the end of double-blind TXA or placebo infusion.
| Placebo (n=60) | TXA 0.5 g (n=58) | TXA 1 g (n=57) | |
|---|---|---|---|
| Age (yr) | 33.1 (5.8) [21–42] | 33.7 (5.5) [23–46] | 33.2 (4.2) [23–42] |
| Weight before pregnancy (kg) | 73.2 (21.3) | 73.8 (21.3) | 75.5 (18.8) |
| Weight at the end of pregnancy (kg) | 84.6 (19.6) | 85.3 (19.7) | 86.3 (15.2) |
| Height (cm) | 163.0 (7.2) | 165.1 (7.5) | 165.3 (7.0) |
| BMI (kg m−2) | 31.6 (6.7) | 31.4 (6.5) | 31.7 (5.4) |
| Gestational age (weeks) | 38.0 (2.4) | 37.8 (2.3) | 38.1 (2.2) |
| Nulliparity, n (%) | 14 (23) | 16 (28) | 14 (25) |
| Illness during pregnancy, n (%) | 46 (77) | 42 (75) | 42 (74) |
| Caesarean delivery indications and causes of postpartum haemorrhage Atony, n (%) |
45 (75) | 41 (71) | 41 (72) |
| Multiple pregnancies, n (%) | 13 (22) | 11 (20) | 10 (18) |
| Previous Caesarean delivery, n (%) | 19 (32) | 14 (24) | 15 (26) |
| Previous postpartum haemorrhage, n (%) | 9 (15) | 12 (21) | 8 (15) |
| Dystocia, n (%) | 6 (10) | 4 (7) | 5 (9) |
| Macrosomia, n (%) | 7 (12) | 4 (7) | 3 (5) |
| Preeclampsia, n (%) | 1 (2) | 2 (3) | 2 (3) |
| Placenta praevia or accreta, n (%) | 14 (24) | 15 (26) | 14 (25) |
| Baseline blood loss at T0 (ml), median (IQR) | 902 [852–1100] | 1038 [900–1200] | 1048 [940–1308] |
| Delay birth inclusion (min) | 39.3 (79.6) | 29.9 (62.1) | 21.8 (30.5) |
| Caesarean delivery duration (min), median (IQR) | 52 [44–71.5] | 63 [48–85] | 51.5 [45–69] |
| General anaesthesia, n (%) | 2 (3) | 3 (5) | 3 (5) |
| Laboratory data | |||
| Haemoglobin (g dl−1) | 10.6 (1.5) | –10.9 (1.3) | 10.6 (1.3) |
| Fibrinogen (g L−1) | 4.3 (0.9) | 4.5 (0.9) | 4.5 (0.8) |
| D-dimer (ng ml−1), median (IQR) | 2850 [3130–6780] | 2925 [1960–6670] | 2950 [2040–3750] |
| Plasmin–antiplasmin complexes (ng ml−1), median (IQR) | 441 [302–1161] | 452 [312–1224] | 403 [295–472] |