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. 2022 Nov 30;14:1013891. doi: 10.3389/fnagi.2022.1013891

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Copyright © 2022 Zeng, Liu, Wang, Ye, Sun, Su, Qiu, Li, Wang, Wang, Ma, Li and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The toxicological parameters of 49 bioactive phytochemicals in Alpinia oxyphylla Miq (AO). (A) The toxicological parameters including the acute oral toxicity (LD50, mg/kg), hepatotoxicity and toxicological endpoints (carcinogenicity, immunotoxicity, mutagenicity, and cytotoxicity) in AO. Red and green circles represent active or inactive, respectively. (B) Numbers of phytochemical with 0 (green), 1 (orange), and 2 (blue) active toxicity endpoints among 49 AO phytochemicals. (C) Molecular docking of ACHE with AO phytochemicals and 5 clinically used acetylcholinesterase (ACHE) inhibitors.