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. 2022 Nov 30;14:1013891. doi: 10.3389/fnagi.2022.1013891

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Copyright © 2022 Zeng, Liu, Wang, Ye, Sun, Su, Qiu, Li, Wang, Wang, Ma, Li and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alpinia oxyphylla Miquel (AO) targets and their phytochemicals targeting neuroinflammation. (A) The PPI network was constructed for the 47 targets of AO associated with neuroinflammation. AO targets specifically localized to microglia were pointed out by red arrows. The darker the color, the higher the degree. (B) AO phytochemicals involved in neuroinflammation ranked according to the numbers of targets. (C) Molecular docking of gingerenone A with proteins involved in neuroinflammation. (D) Molecular docking of the tectochrysin, chrysin and CD38 inhibitor 1 (compound 78c) with CD38.