Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 14;10:180. doi: 10.1186/s40478-022-01480-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022, corrected publication 2024

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 6 — Differential gene expression in male and female αSyn-KO mice. NanoString^® transcriptional profiling was performed on hippocampal RNA from 6-month-old female and male αSyn-KO mice. A Volcano plot of the differentially expressed genes of αSyn-KO females compared to αSyn-KO males at adjusted significance thresholds of P < 0.05 and P < 0.01. Orange indicates upregulated genes, blue indicates downregulated genes. B Venn diagram of differentially expressed genes shows little overlap between WT and αSyn-KO females and males. C Top results for GO and KEGG databases using the female and male αSyn-KO differentially expressed gene list performed with g:Profiler for functional enrichment analysis. D MCL clustering and visualization of Cytoscape clusters was performed using clusterMaker2 based on co-expression data. Analysis revealed EGR1 as a central node in the network as well as several EGR1 target genes (black circles, thickness reflects the number of responsive elements)