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. 2022 Nov 30;13:1054539. doi: 10.3389/fimmu.2022.1054539

Table 4.

Assessment of bias risk using NOS scale for cohort study.

References Representativeness of the exposed cohort Selection of the non-exposed cohort Ascertainment of exposure Demonstration that outcome of interest was not present at start of the study Comparability of cohorts based on the design or analysis Assessment of outcome Was follow-up long enough for outcomes to occur Adequacy of follow up of cohorts
Abji F, 2020 (70) B* A* A* A* A* B*
Abji F, 2020 (BMJ) (70) B* A* A* A* B* A* A* D
Chandran, 2013 (29) B* B* A* A* A* A*
Fuentelsaz-Romero, 2021 (76) B* A* A* A* A* A* C D
Inciarte-Mundo, 2018 (118) B* A* B* A* B* A* A* B*
Iwaszko, 2021 (41) A* A* A* A* A* A* A* A*
Wade, 2020 (40) A* A* B* A* A* B* A* D

1) Representativeness of the exposed cohort A: truly representative of the average in the community*; B: somewhat representative of the average in the community*; C: selected group of users eg nurses, volunteers; D: no description of the derivation of the cohort.

2) Selection of the non-exposed cohort A: drawn from the same community as the exposed cohort* B: drawn from a different source; C: no description of the derivation of the non-exposed cohort.

3) Ascertainment of exposure A: secure record (eg surgical records)*; B: structured interview*; C: written self report; D: no description.

4) Demonstration that outcome of interest was not present at start of study A: yes* B: no.

5) Comparability of cohorts on the basis of the design or analysis A: study controls for … *; B: study controls for any additional factor*.

6) Assessment of outcome A: independent blind assessment*; B: record linkage*; C: self report; D: no description.

7) Was follow-up long enough for outcomes to occur A: yes (select an adequate follow up period for outcome of interest)*; B: no.

8) Adequacy of follow up of cohorts A: complete follow up - all subjects accounted for*; B: subjects lost to follow up unlikely to introduce bias*; C: follow up rate < ::% (select an adequate %) and no description of those lost; D: no statement.