Table 4.
Genes identified in the Pain Questionnaire cohort with their tractability as drug targets using annotations from OpenTargets [109]
| Gene | Small molecule tractable | Small molecule clinical | Antibody tractable | Existing drugs | Development compounds | PDB structures |
|---|---|---|---|---|---|---|
| S100PBP | 0 | 0 | 0 | 0 | 0 | 0 |
| ATP9A | 0 | 0 | 1 | 0 | 0 | 0 |
| KCNB1 | 0.3 | 1 | 1 | 7 | 28 | 0 |
| CLOCK | 0 | 0 | 0 | 0 | 0 | 2 |
| SLC15A4 | 0 | 0 | 1 | 0 | 0 | 0 |
| TMEM232 | 0 | 0 | 0 | 0 | 0 | 0 |
| GPC5 | 0 | 0 | 0.3 | 0 | 0 | 0 |
| PHACTR2 | 0 | 0 | 0.3 | 0 | 0 | 0 |
| AKAP1 | 0 | 0 | 0 | 0 | 0 | 0 |
| USP6NL | 0 | 0 | 0.3 | 0 | 0 | 0 |
| CDON | 0 | 0 | 0.3 | 0 | 0 | 3 |
| INSR | 1 | 0.7 | 0.3 | 20 | 891 | 62 |
| SULF2 | 0 | 0 | 0 | 0 | 0 | 0 |
| SLC6A11 | 0.3 | 0 | 0.3 | 6 | 126 | 0 |