Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 14;612(7941):758–763. doi: 10.1038/s41586-022-05542-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

PMC Copyright notice

Extended Data Fig. 4 — (a) P18, (b) P19, (c) P27, (d) P33, (e) P36, (f) P38. Haplotype diagrams (left) show SARS-CoV-2 spike single genome sequences detected in multiple organs. Spike NH2-terminal domain (NTD), receptor-binding domain (RBD), and furin cleavage site (F) regions are shaded grey, and remaining regions of the spike are shaded white. Ticks with different colors indicate mutations relative to the WA-1 reference sequence; green indicates non-synonymous differences from WA-1 detected in all sequences in the individual; blue indicates synonymous mutations detected variably within the individual, and pink indicates non-synonymous mutations detected variably within the individual. Bar graphs (right) show the percentage of all single genome sequences in the sample matching each haplotype. The spike region of the consensus sequence generated from short read, whole genome sequencing (WGS) of the supernatant of P38 thalamus frozen tissue on Vero E6-TMPRSS2-T2A-ACE2 cells is additional shown at the bottom of (f) for comparison.