TABLE 1.
Measures of pulmonary damage after challenge with CP9 (1.0 × 107 CFU)
| Group | Mean lung wt (g)a | Permeability indexb | PO2/FIO2 (mm Hg)c | BAL protein (mg/ml) | Neutrophils in BALd (mean no./ml) |
|---|---|---|---|---|---|
| Control | 1.3 ± 0.03 | 0.31 ± 0.05 | 400 ± 48 | 5.2 ± 1.1 | 0 |
| CP9 (wt) | 5.3 ± 0.10 | 10.1 ± 2.0 | 84 ± 6.9 | 74.7 ± 18.4 | (3.2 ± 0.9) × 107 |
a
Mean weight in grams ± the standard error in animals that died.
b
Measured at 6 h post-CI administration.
c
FIO2 = 0.8.
d
Mean number measured at 6 h post-CI administration. BAL, bronchoalveolar lavage fluid.