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MPO activity is dependent on initial CI and not on bacterial load over time
| Strain | CI (CFU/lung) | Avg titer with clearance (CFU/lung) | Avg titer with growth (CFU/lung) | MPO activity with bacterial clearance (U/lung) | MPO activity with bacterial growth (U/lung) |
|---|---|---|---|---|---|
| CP9 (wt) | 5.6 × 106 | 2.8 × 105 | 2.8 × 109 | 559 ± 76 | 582 ± 60 |
| CP9 | 1.2 × 107 | 1.8 × 106 | 5.9 × 108 | 622 ± 69 | 644 ± 38 |
| CP9.137 | 7.7 × 107 | 2.9 × 107 | 3.1 × 108 | 454 ± 24 | 493 ± 20 |
