TABLE 3.
Capsule and O-specific antigen significantly alter maximum MPO levels but do not significantly change time to 50% of maximum MPO increases
| Effecta | Estimate | SE | Z score | Pb |
|---|---|---|---|---|
| Effect on maximum MPO level | ||||
| Deleting capsule | 1.9071 | 0.3333 | 5.722 | <0.0001 |
| Deleting O-specific antigen | −0.8787 | 0.2978 | −2.951 | 0.0032 |
| Synergy | −0.2655 | 0.2172 | −1.222 | 0.9028 |
| Effect on time to 50% of increase | ||||
| Deleting capsule | −0.1593 | 0.1095 | −1.455 | 0.1445 |
| Deleting O-specific antigen | 0.1456 | 0.1095 | 1.330 | 0.1834 |
| Synergy | −0.1459 | 0.1057 | −1.381 | 0.1672 |
a
Estimates are expressed as the common logarithm of amount by which the challenge inoculum must be multiplied to produce the same result when the capsule or O-specific antigen is deleted.
b
The effects of deleting the capsule, deleting the side chain, and the synergy were tested for statistical significance by dividing each estimate by its standard error and comparing the resulting Z score to a standard normal distribution. P < 0.05 was considered to be statistically significant.