Figure 4.

Associations of genetically predicted sex hormone-binding globulin levels with diseases in univariable and multivariable Mendelian randomization analysis. BPs, blood pressures; CARDIoGRAMplusC4D, Coronary ARtery DIsease Genome wide Replication and Meta-analysis (CARDIoGRAM) plus The Coronary Artery Disease (C4D) Genetics; CI, confidence interval; CKD Gen, Chronic Kidney Disease Genetics; DIAGRAM, DIAbetes Genetics Replication And Meta-analysis; GFOC, GEnetic Factors for OSteoporosis Consortium; GWAS, genome-wide association study; IVW, inverse variance weighted; MVMR, multivariable Mendelian randomization; OR, odds ratio; UKBB, UK Biobank. MVMR-adjusted lipids were adjusted for high-density lipoprotein cholesterol and triglycerides that were significantly associated with genetically predicted sex hormone-binding globulin levels. MVMR-adjusted BPs were adjusted for both systolic and diastolic blood pressures