Table 1.
Associations of genetically predicted sex hormone-binding globulin and testosterone levels with biomarkers in two-sample Mendelian randomization analysis
| Outcome | Source | Unit | Sample size | Change (95% CI) | P |
|---|---|---|---|---|---|
| Sex hormone-binding globulin | |||||
| Total cholesterol | GLGC | SD | 187 365 | −0.10 (−0.21, 0.02) | 0.096 |
| Low-density lipoprotein cholesterol | GLGC | SD | 173 082 | −0.07 (−0.17, 0.04) | 0.216 |
| High-density lipoprotein cholesterol | GLGC | SD | 187 167 | 0.43 (0.32, 0.53) | <0.001 |
| Triglycerides | GLGC | SD | 177 861 | −0.61 (−0.73, −0.49) | <0.001 |
| Systolic blood pressure | ICBP | mmHg | 757 601 | −2.72 (−3.60, −1.85) | <0.001 |
| Diastolic blood pressure | ICBP | mmHg | 757 601 | −1.25 (−1.77, −0.73) | <0.001 |
| Uric acid | CKD Gen consortium | mg/dL | 288 649 | −0.21 (−0.29, −0.13) | <0.001 |
| Fasting glucose | PAGE study | SD | 13 556 | −0.08 (−0.19, 0.03) | 0.168 |
| Testosterone | |||||
| Total cholesterol | GLGC | SD | 187 365 | −0.22 (−0.38, −0.06) | 0.007 |
| Low-density lipoprotein cholesterol | GLGC | SD | 173 082 | −0.07 (−0.22, 0.07) | 0.300 |
| High-density lipoprotein cholesterol | GLGC | SD | 187 167 | 0.17 (0.02, 0.32) | 0.023 |
| Triglycerides | GLGC | SD | 177 861 | −0.71 (−0.96, −0.46) | <0.001 |
| Uric acid | CKD Gen consortium | mg/dL | 288 649 | −0.13 (−0.29, 0.03) | 0.114 |
CI, confidence interval; CKD Gen, Chronic Kidney Disease Genetics; GLGC, Global Lipids Genetics Consortium; ICBP, International Consortium for Blood Pressure; PAGE, Population Architecture using Genomics and Epidemiology; SD, standard deviation.