Figure 2.

Treatment of metastatic PDAC with mutant KRAS-targeting genetically engineered T-cells. A heavily pretreated patient with metastatic PDAC to the lungs underwent an expiremental immunotherapy that targets mutant KRAS. Autologous T-cells were isolated and transfected with genes encoding two HLA-restricted T-cell receptors targeting KRAS G12D epitopes. The infusion product contained 16.2x10⁹ T cells, and supportive high dose interleukin-2 therapy was administered. Metastatic lung lesions regressed at 1 month follow up, with continued regression at 6-months and an overall partial response rate of 72%.