Table 2.

The details of the core targets.

Gene symbol	Full name	Function
EGFR	Epidermal growth factor receptor	EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation.
JAK2	Janus kinase 2	This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon.
FYN	FYN proto-oncogene, SRC family tyrosine kinase	This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth.
ERBB2	Erb-B2 receptor tyrosine kinase 2	This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.
KIT	KIT proto-oncogene, receptor tyrosine kinase	This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism.
SRC	Src proto-oncogene, non-receptor tyrosine kinase	This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase.