Table V.

Supportive care recommendations in human monkeypox

Wound care	Pain control	Scarring
Maintain clean and moist environment	Multimodal non-opioid analgesia: first line	Prevention
Cleanse wound with gentle soap and water daily	Systemic: acetaminophen, NSAIDs (oral, IV; if tolerated)	Optimize wound care and healing
Apply gelling fiber, foam, or ointment (Vaseline, MediHoney) to clean wound before replacing a fixed dressing (eg, Tegaderm, loose gauze dressing secured by medical tape) daily	Topical: lidocaine preparations, cool packs	Avoid secondary skin infection
Avoid secondary skin infection	Severe, refractory pain	Facilitate resolution of dyspigmentation
Advise patient to avoid manipulating lesions/scabs	Consider hospitalization, opioids, and/or palliative care or pain consultation	Sun protection (avoidance, sunscreen) and fading agents (retinoids, hydroquinone)
Treat secondary skin infections	Pain at mucosal sites and mucosal edema	Cosmetics referral
Topical and/or systemic antibiotics only if clinical evidence of infection	Rectal: lidocaine or other topical numbing agent, hydrocortisone 1%, pramoxine	Laser, peels
Incision and drainage if evidence of abscess	Oropharyngeal: magic mouthwash, lidocaine gel, liquid morphine
Note: Consider consultants for wounds in special sites (eye, anal, or genital lesions)	Note: Monitor for ability to maintain oral intake, IV hydration as needed	Note: Screen for psychological sequelae from scarring and refer to mental health services as appropriate

IV, Intravenous; NSAIDs, non-steroidal anti-inflammatory drugs.