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. Author manuscript; available in PMC: 2023 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2022 Apr 1;68:128718. doi: 10.1016/j.bmcl.2022.128718

Scheme 2 –

Scheme 2 –

synthesis of compounds 16-27. Reagents and conditions: a) methyl 2-bromo-2-phenylacetate, Cs2CO3, DMF, 50°C, 55-79%; b) LiOH, H2O, MeOH, THF, 27-99%; c) 2-aminothiazole, iPr2NEt, HATU, DMF, 60°C, 56-85%; d) aryl amine pinacol boronate, Pd(dppf)Cl2, Na2CO3, 4:1 dioxane:water, 100°C, 24-70%.