Table 7.
ADMET Factors.
| ADMET | Factors | DPDS |
|---|---|---|
| Absorption | Water solubility (log mol/L) | -2.987 |
| Caco-2 permeability (log Papp in 10−6cm/s) | 0.909 | |
| Human intestinal absorption (%) | 98.692 | |
| P-glycoprotein substrate | YES | |
| P-glycoprotein I/II inhibitors | NO | |
| Distribution | CNS permeability (log PS) | -2.426 |
| Human VDss (log L/kg) | -2.018 | |
| Fraction unbound (human)(Fu) | 0.307 | |
| Metabolism | CYP substrates/inhibitors | NO |
| Excretion | Total clearance (log ml/min/kg) | 0.2 |
| Toxicity | AMES toxicity | NO |
| Max. tolerated dose (human)(log mg/Kg/day) | 1.177 | |
| Oral rat Acute Toxicity (LD50)(mol/kg) | 2.651 | |
| hERG l/ll inhibitors | NO | |
| Hepatotoxicity | NO |