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. 2022 Jul 15;13(12):1504–1525. doi: 10.1039/d2md00143h

The ΔTma values (°C) of studied ds-polynucleotides upon addition of ratio rb = 0.3 and of 15a–c, 16a, 16c, 17a, 21a and 21b at pH 7.0 (sodium cacodylate buffer, I = 0.05 mol dm−3).

r b = 0.3 15a 15b 15c 16a 16c 17a 21a 21b
ctDNA 3.3 2.4 1.6 4.4 2.6 3.8 0 0
Poly A–poly U 3.7 1.0 0 0 0 0 NDc NDc
Poly(dA–dT)2 16.9 16.0 16.9 11.0 12.1 11.9 3.1 3.8
a

Difference between Tm value of free polynucleotide and complex with a small molecule; error in ΔTm: ±0.5 °C.

b

r = [compound]/[polynucleotide].

c

Not determined.