Antimicrobial activity of brevicidine and laterocidine analogues 9–26.

Compound	Lipid chain length	Antimicrobial activity (μg mL−1)						% Hemolytic activity
		E. coli ATCC 25922	E. coli ATCC 25922 MCR-1	K. pneumoniae ATCC 13883	A. baumannii ATCC 17961	P. aeruginosa PAO1	S. aureus USA300	Sheep red blood cells
1	C7	4	4	2	4	8	>32	0.8
9	H	>32	>32	>32	>32	16	>32	0.2
10	C2	>32	>32	>32	>32	8	>32	0.2
11	C4	32	32	8	32	16	>32	0.1
12	C6	8	8	4	16	>32	>32	0.3
13	C8	16	16	16	16	8	>32	0.4
14	C10	4	4	4	4	8	32	6.2
15	C12	8	8	8	4	16	32	13.3
16	C14	16	16	32	4	32	>32	18.0
17	C16	>32	>32	>32	32	>32	>32	13.3
2	C9	2	2	2–4	2	4	>32	0.4
18	H	>32	>32	>32	>32	>32	>32	0.2
19	C2	>32	>32	>32	>32	16	>32	0.2
20	C4	16	32	32	>32	8	>32	0.3
21	C6	4	8	8	16	4	>32	0.2
22	C8	2	2	2	4	2	>32	0.2
23	C10	2	2	2–4	2	2	>32	2.1
24	C12	4	4	8	2	8	32	21.5
25	C14	8	8	8	2	8	16	56.2
26	C16	32	32	>32	4	32	32	46.1
Colistin	C8/C9	0.5	8	0.5	≤0.25	4	>32	<0.1%
0.1% TX100	ND	ND	ND	ND	ND	ND	ND	100