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. 2022 Nov 2;38(24):5375–5382. doi: 10.1093/bioinformatics/btac686

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — Stromal cell fractions are correlated with expression levels of LTM selected collagen genes. (A) Human collagen genes are listed with a block plot, with one block indicating one gene. Each column represents a collagen category. The LTMabs values are indicated by the block color. (B) The fraction of cancer-associated fibroblast is positively correlated with expression of COL1A2 in tumor samples from LUAD and LUSC. (C) The fraction of cancer related fibroblast is positively correlated with expression of seven collagen genes selected by LTM (LTMabs ≥ 0.5) in multiple cancer types. (D) The fraction of endothelial cells is positively correlated with expression of COL4A1 in tumor samples from LGG and THCA. (E) The fraction of the endothelial cell is positively correlated with expression of seven collagen genes selected by LTM (LTMabs ≥ 0.5) in multiple cancer types. The 11 cancer types include BLCA, BRCA, HNSC, KIRC, LUAD, LGG, LUSC, PRAD, SKCM, STAD and THCA from TCGA database