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. 2022 Nov 30;12:1049345. doi: 10.3389/fonc.2022.1049345

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Copyright © 2022 Wen, Sun, Luo, Fu, Qiu, Li, Xu, Wu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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COL10A1-DDR2 axis promotes EMT in PDAC cells through activation of MEK/ERK pathway. (A) GSEA validated EMT-related pathways in high COL10A1 expression PDAC cohorts of GSE15471 dataset. (B) The effect of COL10A1 on the expressions of EMT signaling proteins by Immunofluorescence. (C) The effect of COL10A1 and DDR2 on the expressions of EMT signaling proteins by Western blot. (D) Western blot detection of the effect of overexpression of DDR2 on protein expression changes in the EMT pathway induced by interference with COL10A1. (E) Western blot analyses of MEK/ERK pathway proteins in the indicated cells. (F) The protein expression of EMT pathway was detected by western blot in PDAC cells after treated with ERK inhibitor SCH772984. (G) H&E staining and IHC staining of COL10A1, DDR2, P-ERK, E-cadherin, N-cadherin and Vimentin in PDAC orthotopic models. Scale bars, 20 μm.