Time course of P. yoelii yoelii YM infection in groups of 5 BALB/c mice immunized with either PBS (A), purified AMA-1 protein (B), or recombinant GST–MSP-119 (C), together with Freund's adjuvant. Mice were challenged with 5,000 parasitized erythrocytes i.v. at day 0, and the parasitemia was monitored by microscopy every 2 days on blood films stained with Giemsa's reagent. The results for individual mice are shown.