Table 1.
Univariable analysis of prognostic factors.
| Variable (n) | Median survival in months (95% CI) | P value |
|---|---|---|
| Gender | .914 | |
| Male (197) | 12.1 (10.9–13.2) | |
| Female (98) | 13 (10.9–15.0) | |
| Age (years) | .705 | |
| ≤60 (113) | 13 (11.4–14.6) | |
| >60 (182) | 12.1 (10.3–13.8) | |
| Blood types | .750 | |
| A (87) | 13 (11.2–14.8) | |
| B (102) | 13 (11.4–15.6) | |
| AB (36) | 12.1 (8.0–16.2) | |
| O (70) | 10 (8.0–12.0) | |
| Treatment category‡ | <.001*** | |
| R0 resection (96) | 21 (13.7–28.3) | |
| R1/R2 resection (86) | 13.8 (12.3–15.3) | |
| ERBD/PTCD (113) | 8.7 (8.0–9.4) | |
| ALB(g/L)* | <.001*** | |
| <35 (156) | 9 (8.4–9.6) | |
| ≥35 (1390) | 19.7 (17.1–22.3) | |
| PAB (g/L)* | .015* | |
| <200 (200) | 11.5 (10.2–12.8) | |
| ≥200 (95) | 14 (12.0–16.0) | |
| TBIL (μmol/L)* | .386 | |
| <200 (116) | 13.1 (11.3–14.9) | |
| ≥200 (179) | 12.0 (10.1–13.9) | |
| GGT (U/L)* | .512 | |
| <90 (21) | 10.6 (4.8–16.4) | |
| ≥90 (274) | 12.4 (11.3–13.5) | |
| TC (mmol/L)* | .922 | |
| <6.22 (160) | 12.7 (11.3–14.1) | |
| ≥6.22 (135) | 12 (10.0–14.0) | |
| CA19-9 (U/mL) | .003** | |
| <1000 (197) | 14.0 (12.6–15.4) | |
| ≥1000 (98) | 9.9 (9.1–10.7) | |
| Differentiation grade‡ | .556 | |
| Poor (77) | 14.2 (10.8–17.6) | |
| Moderate (90) | 20.4 (13.8–27.0) | |
| Well (15) | 18.6 (12.3–25.0) | |
| Distant metastasis† | <.001*** | |
| Yes (224) | 14.2 (12.6–15.8) | |
| No (71) | 7.3 (6.0–8.6) | |
| Bismuth-Corlette type | <.001*** | |
| I (36) | 29.8 (15.9–43.7) | |
| II (58) | 27.3 (25.3–29.3) | |
| IIIA (71) | 10.4 (9.6–11.2) | |
| IIIB (66) | 11.6 (9.2–14.0) | |
| IV (64) | 8.9 (7.7–10.1) | |
| Tumor diameter (cm)† | <.001*** | |
| ≤3 (176) | 14.0 (12.6–15.4) | |
| >3 (119) | 10.6 (9.6–11.6) | |
| Number of tumours† | .714 | |
| 1 (285) | 12.3 (10.9–13.7) | |
| ≥2 (10) | 14.0 (7.8–20.2) | |
| Vascular encasement † | .037* | |
| No (214) | 13.5 (12.1–14.8) | |
| Yes (81) | 10.2 (8.9–11.5) | |
| ECOG grade | <.001*** | |
| 0 (40) | 20.4 (13.4–27.4) | |
| 1/2 (240) | 12.1 (10.8–13.4) | |
| 3/4 (15) | 5.8 (5.51–6.08) |
ALB = albumin, CA19-9 = carbohydrate antigen 19-9, ECOG = Eastern Cooperative Group, ERBD = endoscopic retrograde biliary drainage, GGT = glutamyl transferase, PAB = prealbumin, PTCD = percutaneous transhepatic cholangiography and drainage, R0 = resection was defined as pathologically negative surgical margins by the naked eye, R1/R2 = resection was defined as positive microscopic resection margins (R1 resection) or positive macroscopic resection margins (R2 resection), TBIL = total bilirubin, TC = total cholesterol.
*
The diagnosis of the measured value.
†
Combining imaging data, enhancement CT > MRI > ultrasound.
‡
Pathological examination.
*
P < .05.
**
P < .01.
***
P < .001.