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. 2022 Nov 30;13:1029085. doi: 10.3389/fimmu.2022.1029085

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Copyright © 2022 Kulle, Thanabalasuriar, Cohen and Szydlowska

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macrophages in the lung. Location of tissue-resident macrophages in the lung and their distinguishing surface markers at steady-state. Alveolar macrophages located within the alveolar lumen express high levels of SiglecF and CD11c, and low levels of CD11b. Interstitial macrophages located in the alveolar interstitium express low levels of Lyve1, high levels of MHCII, and are CD206 negative. Interstitial macrophages located in the bronchial interstitium express high levels of Lyve1, low levels of MHCII, and are CD206 positive. Both interstitial macrophage subsets express low levels of CD11c and high levels of CD11b.