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. 2022 Dec 7;2022:3373828. doi: 10.1155/2022/3373828

Figure 6.

Figure 6

Fer-1 administration alleviates IHC synapse loss and ANF degeneration after noise exposure. (a) Representative pictures of ribbon synapse loss in IHCs caused by noise (presynaptic structures, red; postsynaptic structures, green; IHCs, blue). Pictures were taken of the middle turn of the cochlea, which corresponded to ~16 kHz, scale bar = 20 μm. (b) Representative pictures of ANF degeneration caused by noise (ANFs, red; HCs, green). Scale bar = 20 μm. (c) Quantification of “paired” synapses in IHCs corresponding to ~16 kHz 14 d after noise exposure; n = 3 for each condition. (d) Quantification of TuJ1-immunolabeled ANFs 28 d after noise exposure; n = 3 for each condition. ∗∗∗∗p < 0.0001; ∗∗∗p < 0.001; ∗∗p < 0.01; ns: not significant.