Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 7;2022:3373828. doi: 10.1155/2022/3373828

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Peng-Wei Ma et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fer-1 treatment exerts protective effects against NIHL partially by suppressing ferroptosis and apoptosis. (a) The expression levels of TfR1, P53, GPX4, ACSL4, AIFM2, AIF, SOD2, and BAX in the mouse cochlea exposed to different treatment combinations. (B) Semiquantification of the gray values of the TfR1, P53, GPX4, ACSL4, AIFM2, AIF, SOD2, and BAX bands. ^∗∗∗∗p < 0.0001; ^∗∗p < 0.01; ns: not significant. (c) HEK293 cells transfected with endogenously FLAG tagged P53 were lysed for immunoprecipitation with anti-FLAG and anti-4-HNE antibodies. (d) Ferrostatin-1 protects hearing by suppressing ferroptosis and apoptosis.