Table 2. List of microRNAs targeting TP53 gene. The expression of microRNA s in different states of comparison, p -values for survival curve analysis .
| miRNA name | Normal vs. Primary tumor | Survival curve | TP53 mutant vs. non-mutant | Normal vs. TP53 mutant | Expression of microRNA in TP53 mutant | Normal vs. TP53 non-mutant |
|---|---|---|---|---|---|---|
| hsa-miR-3922–5p | 5.5 × 10 −16, a | 0.14 | 6.5 × 10 −1 | 5.55 × 10 −16, a | Upregulated | 1.72 × 10 −12, a |
| hsa-miR-381–3p | 2.08 × 10 −2, a | 0.064 | 9.96 × 10 −1 | 2.07 × 10 −2 | Downregulated | 2.08 × 10 −2 |
| hsa-miR-6842–3p | 3.675 × 10 −13, a | 0.55 | 1.38 × 10 −1 | 1.02 × 10 −9, a | Upregulated | 3.19 × 10 −9, a |
| hsa-miR-491–5p | 5.3362 × 10 −2, a | 0.92 | 1.28 × 10 −1 | 3.2 × 10 −2 | Downregulated | 1.610 −1 |
| hsa-miR-4742–5p | 8.426 × 10 −4, a | 0.66 | 1.510 −1 | 1.02 × 10 −4, a | Upregulated | 3.3 × 10 −3, a |
| hsa-miR-1305 | <10 −12, a | 0.23 | 5.210 −1 | 1.62 × 10 −12, a | Upregulated | 4.2 × 10 −13, a |
| hsa-miR-548d-3p | 1.19 × 10 −3, a | 0.91 | 1.614 × 10 −1 | 1.78 × 10 −2, a | Upregulated | 3.17 × 10 −3, a |
| hsa-miR-520b-5p | 1.33 × 10 −1 | 0.26 | 3.86 × 10 −1 | 3.78 × 10 −5, a | Upregulated | 2.83 × 10 −1 |
| hsa-miR-7850–5p | 1.404 × 10 −10, a | 0.71 | 4.04 × 10 −1 | 3.9 × 10 −9, a | Upregulated | 1.78 × 10 −5, a |
| hsa-miR-519a-2–5p | 1.903 × 10 −1 | 0.42 | 3.76 × 10 −1 | 2.16 × 10 −3, a | Upregulated | 3.010 −1 |
| hsa-miR-4728–5p | 2.03 × 10 −2 | 0.9 | 2.55 × 10 −1 | 1.30 × 10 −1 | Upregulated | 7.30 × 10 −2 |
| hsa-miR-3652 | 1.65 × 10 −12, a | 0.66 | 5.44 × 10 −1 | 1.60 × 10 −10, a | Upregulated | 4.5 × 10 −11, a |
| hsa-miR-223–3p | 1.29 × 10 −1 | 0.041 | 4.2 × 10 −1 | 9.12 × 10 −2 | Upregulated | 2.56 × 10 −1 |
| hsa-miR-1294 | 2.04 × 10 −1 | 0.94 | 1.93 × 10 −1 | 1.83 × 10 −1 | Downregulated | 4.70 × 10 −1 |
| hsa-miR-4677–3p | <10 −12, a | 0.51 | 7.31 × 10 −3, a | 1.62 × 10 −12, a | Upregulated | 1.62 × 10 −12, a |
| hsa-miR-4725–5p | 2.2 × 10 −12, a | 0.64 | 1.46 × 10 −2, a | 3.46 × 10 −12, a | Upregulated | 1.75 × 10 −5, a |
| hsa-miR-504–5p | 1.799 × 10 −3, a | 0.05 | 6.34 × 10 −1 | 7.38 × 10 −3, a | Downregulated | 1.92 × 10 −3, a |
| hsa-miR-4640–5p | 8.73 × 10 −9, a | 0.82 | 6.38 × 10 −1 | 2.60 × 10 −8, a | Upregulated | 2.45 × 10 −8, a |
| hsa-miR-149–3p | 3.59 × 10 −3, a | 0.78 | 3.46 × 10 −1 | 5.58 × 10 −3, a | Downregulated | 9.36 × 10 −2 |
| hsa-miR-330–3p | 1.62 × 10 −12, a | 0.36 | 1.210 −1 | 1.66 × 10 −12, a | Upregulated | 1.63 × 10 −12, a |
| hsa-miR-7110–5p | 5.77 × 10 −9, a | 0.074 | 1.28 × 10 −2, a | 2.65 × 10 −9, a | Upregulated | 4.36 × 10 −4, a |
| hsa-miR-6842–5p | 3.67 × 10 −13, a | 0.55 | 1.38 × 10 −1 | 1.02 × 10 −9, a | Upregulated | 3.19 × 10 −9, a |
| hsa-miR-374a-3p | 6.53 × 10 −3, a | 0.22 | 8.46 × 10 −1 | 3.26 × 10 −2, a | Downregulated | 3.39 × 10 −2, a |
| hsa-miR-4529–3p | 9.64 × 10 −5, a | 0.088 | 1.36 × 10 −1 | 6.55 × 10 −4, a | Upregulated | 1.00 × 10 −6, a |
| hsa-miR-6737–5p | 2.28 × 10 −6, a | 0.19 | 7.010 −2 | 1.26 × 10 −6, a | Upregulated | 7.82 × 10 −4, a |
| hsa-miR-4726–5p | 2.010 −8, a | 0.37 | 6.72 × 10 −1 | 5.22 × 10 −7, a | Upregulated | 3.13 × 10 −6, a |
| **hsa-miR-421 | 1.110 −16, a | 0.018 | 1.15 × 10 −4, a | 1.62 × 10 −12, a | Upregulated | 1.62 × 10 −12, a |
| hsa-let-7f-5p | 2.710 −2, a | 0.25 | 5.97 × 10 −1 | 3.14 × 10 −2, a | Downregulated | 1.23 × 10 −1 |
| hsa-miR-548f-5p | <10 −12, a | 0.006 | 5.28 × 10 −2 | 1.810 −10, a | Upregulated | 3.53 × 10 −10, a |
| hsa-miR-98–5p | 7.5 × 10 −2 | 0.71 | 4.43 × 10 −4, a | 5.06 × 10 −3, a | Upregulated | 8.76 × 10 −1 |
| hsa-let-7b-5p | 3.77 × 10 −2, a | 0.74 | 2.47 × 10 −1, a | 4.04 × 10 −2, a | Downregulated | 1.62 × 10 −1 |
| hsa-let-7 g-5p | 5.60 × 10 −2 | 0.026 | 4.18 × 10 −5, a | 2.63 × 10 −3 | Downregulated | 7.010 −1 |
| hsa-miR-5703 | 1.63 × 10 −5, a | 0.37 | 4.90 × 10 −1 | 7.75 × 10 −5, a | Upregulated | 3.77 × 10 −4, a |
| hsa-miR-6731–5p | 7.610 −10, a | 0.67 | 1.96 × 10 −2 | 3.32 × 10 −7, a | Upregulated | 1.310 −9, a |
| hsa-let-7a-5p | 2.02 × 10 −4, a | 0.48 | 7.56 × 10 −3, a | 6.42 × 10 −5, a | Downregulated | 7.56 × 10 −3, a |
| hsa-let-7i-5p | 1.38 × 10 −4, a | 0.87 | 9.98 × 10 −1 | 4.010 −4, a | Upregulated | 7.00 × 10 −4, a |
| hsa-let-7e-5p | 7.2 × 10 −2 | 0.055 | 2.12 × 10 −1 | 2.60 × 10 −2, a | Upregulated | 3.056 × 10 −1 |
| **hsa-let-7c-5p | 1.110 −16, a | 0.036 | 2.30 × 10 −3, a | 1.63 × 10 −12, a | Downregulated | 1.62 × 10 −12, a |
| hsa-miR-4516 | 2.60 × 10 −1 | 0.017 | 4.50 × 10 −1 | 5.38 × 10 −1 | Downregulated | 3.2310 −10, a |
| hsa-miR-194–3p | 2.15 × 10 −3, a | 0.81 | 1.810 −2, a | 7.87 × 10 −2 | Upregulated | 1.58 × 10 −4, a |
| hsa-miR-6509–5p | 3.06 × 10 −3, a | 0.39 | 9.93 × 10 −2 | 2.00 × 10 −2, a | Upregulated | 4.4 × 10 −4, a |
| hsa-miR-636 | 2.42 × 10 −14, a | 0.8 | 8.19 × 10 −2 | 6.25 × 10 −14, a | Upregulated | 1.36 × 10 −7, a |
| hsa-miR-939–3p | 1.62 × 10 −12, a | 0.35 | 9.010 −02 | 1.99 × 10 −15, a | Upregulated | 5.45 × 10 −10, a |
| hsa-miR-3187–5p | 1.46 × 10 −13, a | 0.11 | 1.22 × 10 −1 | 1.78 × 10 −12, a | Upregulated | 2.03 × 10 −5, a |
| hsa-miR-612 | 2.48 × 10 −2, a | 0.96 | 1.73 × 10 −1 | 1.67 × 10 −1 | Upregulated | 3.59 × 10 −2, a |
| hsa-let-7d-5p | <10 −12, a | 0.65 | 2.74 × 10 −1 | 10 −12, a | Upregulated | 1.62 × 10 −12, a |
| hsa-miR-150–5p | 1.97 × 10 −1 | 0.063 | 2.910 −6, a | 4.3 × 10 −1 | Upregulated | 1.10 × 10 −3 |
| hsa-miR-6766–5p | 7.39 × 10 −1 | 0.42 | 8.88 × 10 −1 | 7.510 −1 | Upregulated | 8.24 × 10 −1 |
| hsa-miR-21–3p | 1.62 × 10 −12, a | 0.26 | 9.89 × 10 −2 | 10 −12, a | Upregulated | 1.62 × 10 −12, a |
| hsa-miR-22–3p | 4.77 × 10 −1 | 0.5 | 2.38 × 10 −4, a | 8.06 × 10 −1 | Upregulated | 1.14 × 10 −1 |
| hsa-miR-433–5p | 1.84 × 10 −2, a | 0.87 | 5.74 × 10 −2 | 2.49 × 10 −2, a | Upregulated | 9.40 × 10 −3, a |
a, the values represent statistically significant difference in the expression profile between the groups. A p value less than 0.05 is considered to be significant