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. 2022 Jun 14;29(12):1854–1865. doi: 10.1038/s41417-022-00484-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A As described in Fig. 1A, mice were sacrificed after 2 days post-treatment. CD45⁺ cells were isolated from non-parenchymal cells (NPCs). Gating strategy to analyze CD45⁺ cells isolated from the LM. B MDSC cell population (CD11b⁺Gr1⁺), C monocytic MDSCs (M-MDSC; CD11b⁺Ly6C^+/hiLy6G^/lo) and D granulocytic MDSCs (G-MDSC; CD11b⁺Ly6C^-/loLy6G^+/hi) were measured. E Gating strategy of the phenotypic analysis of CD45⁺ derived macrophages that were isolated from the LM. F M1-macrophage cell population (F4/80⁺CD38⁺Egr2^-) and G M2 macrophage cell population (F4/80⁺CD38^-Egr2⁺) were determined. Each animal data is represented by a scattered plot and presented as mean ± SEM from at least three different experiments. Students’ t-test was performed for group-wise comparison and are described in each graph.