Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 21;40(12):1845–1854. doi: 10.1038/s41587-022-01382-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a, qPCR analysis of virus gRNA copy numbers in oropharyngeal swabs and lung homogenates at day 2/3 or day 5 p.i. b, Titration of replication-competent virus from lung homogenates as plaque assay on Vero E6 cells at day 2/3 or day 5 p.i. Red symbols: animals taken out of the study at day 2 due to severe clinical symptoms. Orange symbols: animals taken out of the study at day 3 due to severe clinical symptoms. Data are represented by the median and values for individual animals. Number of animals analyzed per treatment group at day 2/3; day 5 p.i.: ensovibep 0 hours: n = 5; 5 / mAb cocktail 0 hours: n = 4; 5 / ensovibep 24 hours: n = 5; 5 / mAb cocktail 24 hours: n = 6; 6 / placebo, infected: n = 8; 4 / placebo, non-infected: n = 3; 3. Some animals were excluded from the final analysis due to low drug exposure, likely due to a failure of i.p. injections. These animals were excluded from all analyses. Statistics: two-tailed Mann–Whitney test. P values: not significant (NS) = P > 0.05; *a: 0.0295; *b: 0.0162; *c: 0.0159; *d: 0.0159; *e: 0.0317; *f: 0.0100; *g: 0.0317; *h: 0.0159; *i: 0.0159; *k: 0.0190; *l: 0.0159; **a: 0.0016; **b: 0.0040; **c: 0.0016; **d: 0.0159; **e: 0.0079; **f: 0.0079; **g: 0.0048; ***a: 0.0007; ***b: 0.0008; ***c: 0.0008; ***d: 0.0007.