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. 2022 Jul 21;40(12):1845–1854. doi: 10.1038/s41587-022-01382-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — Histopathologic lesions were scored semi-quantitatively and scores plotted as graphs for histologic signs of general inflammation and histologic parameters of bronchiolar, alveolar and vascular lesions at day 2/3 p.i (a) or day 5 p.i. (b). Data are represented as mean values +/- SEM. Number of animals analyzed per treatment group at days 2/3; day 5 p.i.: Ensovibep 0 h: n = 5; 5 / mAb cocktail 0 h: n = 4; 5 / Ensovibep 24 h: n = 5; 5 / mAb cocktail 24 h: n = 6; 6 / Placebo, infected: n = 8; 4 Placebo, non-infected: n = 3; 3. The rational for excluding animals is the identification of animals with low drug exposure, likely due to a failure of i.p. injections.