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. 2022 Jul 22;29(12):1918–1929. doi: 10.1038/s41417-022-00507-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Human organoid-fibroblast co-cultures consisting of JAM-A negative or JAM-A positive fibroblasts were infected with R124 at MOI 10. 7 days post-infection, organoid-fibroblast co-cultures were embedded and stained for σ3 protein. Three different JAM-A negative (top panel) and JAM-A positive (bottom panel) are shown. Scale bar, 50 μm. B 2D co-cultures of KPC3 tumor cells (mCerulean) with JAM-A negative (CAF1) or JAM-A positive (CAF3) fibroblasts (mRuby) after infection with R124, jin-3, or mock control two days post-infection. Scale bar, 500 μm. C Cell viability of KPC3 tumor-fibroblast co-cultures two days post-infection. Two-way ANOVA for R124 and jin-3 MOI 10 conditions, *** = P ≤ 0.0001.