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. 2022 Jul 22;29(12):1918–1929. doi: 10.1038/s41417-022-00507-9

Fig. 6. The C-terminal PDZ-domain of JAM-A mediates reovirus-induced apoptosis in fibroblasts.

Fig. 6

A Real-time microscopy (T = 72 h) of Caspase3/7 cleavage in hPS1 pancreatic stellate cells expressing different JAM-A constructs after infection with R124 (top row) or jin-3 (bottom row).. Scale bar, 250 μm. B Quantification of Caspase3/7 signal in Relative Fluorescence Units for the entire duration of the experiment (72 h). Two-way ANOVA, *** = P ≤ 0.0001 C Relative caspase 3/7 activation in hPS1 pancreatic stellate cells expressing different JAM-A constructs as compared to the vector control.