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. 2022 Jul 4;40(12):1823–1833. doi: 10.1038/s41587-022-01379-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a,e Quantification of single cell events using individual markers and marker combinations (including standard cell types). Bars are mean ± s.e.; n = 3 reservoirs from two to three tumors. MMTV-PyMT mice with late stage spontaneously growing tumors implanted with IMD for three days were used. Significance was calculated by paired sample one tailed t-test. b, Gray scale single channel images of depicted markers at the palbociclib-delivery reservoir. Arrow indicates the source and direction of drug release. Scale bar; 100 µm. c,f Presentation of key response cell types (biomarker combination displayed) in XY space. d, Distance based clustering of CSF1R, CD31 and Ki67 positive cells as a set of XY coordinates. Individual clusters were identified by minimum 10 cells within maximum distance 50 µm, 75 µm and 30 µm, respectively. Clusters were merged together if present within the maximum distance range. Coordinate [0,0] identifies the drug source. Direction of the drug release is upwards.