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. 2022 Jul 4;40(12):1823–1833. doi: 10.1038/s41587-022-01379-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, Quantification of single cell events using individual markers and marker combinations (including standard cell types). Bars are mean ± s.e.; n = 3 reservoirs from two tumors from two mice. MMTV-PyMT mice with late stage spontaneously growing tumors implanted with IMD for three days were used. Significance was calculated by paired sample one tailed t-test. b, Gray scale single channel images of depicted markers at the panobinsotat-delivery reservoir. Magnified area (bottom) is shown by yellow rectangle. Hashed line shows the IMD border. Scale bar; 100 µm. c, Presentation of key response cell types (biomarker combination displayed) in XY space. Coordinate [0,0] identifies the drug source. The direction of the drug release is upward. d, CD8 (red AEC signal) and hematoxylin (blue) staining of tumors from ErbB2deltaEx16 mice treated with diluent (control) and panobinostat systemically for seven days. The experiment was repeated twice with similar results. Scale bar, 100 µm.