Table 2.
Sub-group analysis of anti-SARS-CoV2 spike IgG (BAU/mL) titers, geometric means (95%CI), 14 days post 2nd dose, according to vaccine group.
| Group 1 ChAdOx1/ChAdOx1 (8w) (n = 100) |
Group 2 ChAdOx1/mRNA-1273 (8w) (n = 100) |
Group 3 ChAdOx1/mRNA-1273 (4w) (n = 100) |
Group 4 mRNA/mRNA-1273 (4w) (n = 99) |
||
|---|---|---|---|---|---|
| Gender | Male | 184.8 (131.3–260.2) | 1931.0 (1400.2–2663.0) | 2921.2 (2243.9–3802.9) | 3804.1 (3207.5–4511.6) |
| Female | 196.5 (163.6–235.9) | 2436.0 (2099.8–2826.0) | 3393.9 (2949.5–3905.3) | 3783.4 (3398.4–4211.9) | |
| M: F | 20: 80 | 19: 81 | 22: 78 | 40: 59 | |
| p-value | 0.762 | 0.177 | 0.316 | 0.954 | |
| Local erythema | Yes | – | 2628.4 (1441.2–4793.4) | 3932.6 (1881.9–8217.9) | 4409.7 (3111.1–6250.3) |
| No | 194.1 (165.5–227.5) | 2306.6 (2006.6–2651.4) | 3246.2 (2863.0–3680.7) | 3734.9 (3389.9–4115.0) | |
| Y: N | 0: 100 | 8: 92 | 6: 94 | 9: 90 | |
| p-value | – | 0.601 | 0.463 | 0.306 | |
| Local swelling | Yes | – | 2125.5 (1458.8–3096.7) | 3458.2 (2312.5–5171.7) | 5368.8 (4124.4–6988.7) |
| No | 194.1 (165.5–227.5) | 2369.1 (2048.0–2740.5) | 3253.9 (2859.0–3703.3) | 3630.4 (3297.8–3996.5) | |
| Y: N | 0: 100 | 15: 85 | 15: 85 | 11: 88 | |
| p-value | – | 0.568 | 0.726 | 0.007∗ | |
| Local pain | Yes | 209.0 (169.4–257.8) | 2445.5 (2086.1–2866.8) | 3243.2 (2860.2–3677.5) | 3795.0 (3445.8–4179.7) |
| No | 172.0 (134.2–220.3) | 2033.1 (1576.8–2621.3) | 4423.9 (2006.7–9753.0) | 3729.7 (2712.3–5128.8) | |
| Y: N | 62: 38 | 74: 26 | 96: 4 | 93: 6 | |
| p-value | 0.239 | 0.231 | 0.326 | 0.935 | |
| Fever ≥ 38 °C | Yes | 155.4 (74.1–325.6) | 2711.2 (2104.7–3492.5) | 3433.0 (2920.1–4035.8) | 3959.4 (3453.1–4540.0) |
| No | 197.3 (167.3–232.9) | 2170.7 (1853.5–2542.3) | 3110.2 (2565.4–3770.6) | 3672.7 (3233.8–4171.2) | |
| Y: N | 7: 93 | 32: 68 | 55: 45 | 42: 57 | |
| p-value | 0.449 | 0.124 | 0.429 | 0.427 | |
| Arthralgia/arthritis | Yes | 667.5 (−) | 3148.1 (2380.7–4162.9) | 3345.6 (2308.0–4849.6) | 4001.0 (2486.6–6437.7) |
| No | 191.7 (163.5–224.6) | 2245.8 (1941.4–2597.9) | 3275.4 (2869.7–3738.6) | 3776.2 (3432.6–4154.3) | |
| Y: N | 1: 99 | 11: 89 | 12: 88 | 7: 92 | |
| p-value | 0.122 | 0.117 | 0.912 | 0.752 | |
| Nausea/vomit | Yes | 113.3 (5.3–2445.4) | 2636.6 (1615.6–4302.9) | 4278.6 (2614.5–7002.1) | 4392.1 (2491.3–7743.2) |
| No | 196.2 (167.0–230.6) | 2309.3 (2005.6–2658.9) | 3209.1 (2824.3–3646.3) | 3762.2 (3421.5–4136.9) | |
| Y: N | 2: 98 | 7: 93 | 8: 92 | 5: 94 | |
| p-value | 0.340 | 0.618 | 0.207 | 0.468 | |
| Chills | Yes | 190.8 (133.1–273.6) | 2515.0 (2054.2–3079.2) | 3608.9 (3038.3–4286.5) | 4074.6 (3559.7–4663.8) |
| No | 194.7 (162.7–233.0) | 2160.1 (1805.7–2584.1) | 2976.5 (2496.2–3549.1) | 3603.7 (3174.8–4090.6) | |
| Y: N | 16: 84 | 50: 50 | 51: 49 | 41: 58 | |
| p-value | 0.928 | 0.261 | 0.119 | 0.194 | |
| Headache | Yes | 207.4 (161.3–266.8) | 2237.4 (1860.2–2691.1) | 3446.8 (2803.4–3995.5) | 3658.8 (3222.6–4153.9) |
| No | 188.6 (153.9–231.2) | 2445.5 (2001.6–2987.8) | 3214.1 (2701.1–3824.5) | 3892.8 (3408.6–4445.7) | |
| Y: N | 30: 70 | 54: 46 | 53: 47 | 42: 57 | |
| p-value | 0.589 | 0.513 | 0.745 | 0.512 | |
| Myalgia | Yes | 211.5 (163.5–273.6) | 2339.0 (1970.6–2776.2) | 3356.7 (2963.6–3802.0) | 3777.6 (3419.9–4172.7) |
| No | 180.4 (147.3–220.8) | 2313.5 (1860.4–2877.0) | 2629.6 (1434.6–4820.2) | 3895.9 (2936.0–5169.8) | |
| Y: N | 46: 54 | 68: 32 | 91: 9 | 87: 12 | |
| p-value | 0.324 | 0.940 | 0.259 | 0.830 | |
| Fatigue | Yes | 197.3 (157.5–247.3) | 2410.7 (2025.6–2869.2) | 3226.8 (2849.4–3654.1) | 3774.2 (3403.1–4185.8) |
| No | 190.1 (151.0–239.5) | 2162.3 (1769.6–2642.1) | 3919.5 (2103.2–7304.3) | 3891.0 (3150.7–4805.4) | |
| Y: N | 55: 45 | 69: 31 | 92: 8 | 84: 15 | |
| p-value | 0.819 | 0.458 | 0.370 | 0.815 | |
| Systemic Rash | Yes | 170.7 (19.3–1508.3) | 2188.9 (1414.9–3386.2) | 3439.6 (1966.6–6016.0) | 3635.7 (2115.9–6247.1) |
| No | 195.4 (168.1–227.1) | 2349.0 (2035.6–2710.5) | 3270.5 (2879.0–3715.4) | 3802.0 (3457.4–4181.0) | |
| Y: N | 5: 95 | 11: 89 | 8: 92 | 6: 93 | |
| p-value | 0.872 | 0.745 | 0.826 | 0.820 |
IgG: immunoglobulin G, BAU/mL: binding antibody units/mL, CI: confidence interval.