Table 1.
Defined relevant peptide and HIP sequences
| Peptide sequence | Peptide origin | HIP-reactive T cells |
|---|---|---|
| Homo sapiens | ||
| EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ | C-peptide | |
| EAEDLQVGQVELGGGPGAGSLQPLAL | Des-(27-31)-C-peptide | |
| EAEDLQVGQVELGGGPGAGSLQPLAL-EAEDLQVGQVELGGG… | HIP11 (human) | E2, GSE.8E3 |
| NOD mice | ||
| EVEDPQVAQLELGGGPGAGDLQTLALEVAQQ | C-peptide (insulin 2) | |
| EVEDPQVAQLELGGGPGAGDLQTLAL | Des-(27-31)C-peptide | |
| EVEDPQVAQLELGGGPGAGDLQTLAL-EVEDPQVAQLELGGG… | HIP11 (mouse) | NY4.1 |
| EVEDPQVAQLELGGGPGAGDLQTLAL-WSRMDQLAKELTAE | 2.5HIP | BDC-2.5, BDC-10.1, |
| WSRMDQLAKELTAE | ChgA: WE14 | BDC-9.46 |
| WSRMDQ | ChgA: WQ6 | |
| EVEDPQVAQLELGGGPGAGDLQTLAL-NAARDPNRESLDFLLV | 6.9HIP | BDC-6.9, BDC-9.3 |
| NAARDPNRESLDFLLV | IAPP: IAPP2 |