Table 4.

Interaction effects among drinking class, within-person age change, and cohort-age per NMF-derived pattern.

Pattern	β	SD	df	t	p	q	Adj. R2
Drinking class x within-person age change interaction1
1	0.031	0.075	1615.1	0.416	0.678	0.790	0.909
2	−0.033	0.073	1613.5	−0.458	0.647	0.790	0.895
3	0.126	0.086	1618.6	1.475	0.140	0.327	0.897
4	0.096	0.083	1616.5	1.156	0.248	0.433	0.890
5	−0.002	0.058	1615.8	−0.033	0.973	0.973	0.898
6	0.162	0.065	1614.1	2.480	0.013	0.093	0.901
7	−0.073	0.046	1609.2	−1.592	0.112	0.327	0.916
Drinking class x cohort-age interaction2
1	0.237	0.036	1687.5	6.629	<0.001	<0.001	0.912
2	0.135	0.035	1686.5	3.887	<0.001	<0.001	0.896
3	0.238	0.041	1702.9	5.817	<0.001	<0.001	0.899
4	0.249	0.040	1700.3	6.271	<0.001	<0.001	0.893
5	0.134	0.028	1699.3	4.847	<0.001	<0.001	0.899
6	0.213	0.031	1693.4	6.867	<0.001	<0.001	0.903
7	0.031	0.022	1663.6	1.386	0.166	0.166	0.916
Within-person age change x cohort-age interaction3
1	0.161	0.012	1597.5	13.339	<0.001	<0.001	0.919
2	0.046	0.012	1596.8	3.757	<0.001	<0.001	0.896
3	0.167	0.014	1598.5	11.990	<0.001	<0.001	0.906
4	0.153	0.014	1596.5	11.233	<0.001	<0.001	0.898
5	0.106	0.009	1596.1	11.227	<0.001	<0.001	0.905
6	0.140	0.011	1595.1	13.340	<0.001	<0.001	0.910
7	0.012	0.008	1597.0	1.534	0.125	0.125	0.916
Drinking class x within-person age change x cohort-age interaction4
1	0.161	0.024	1621.7	6.810	<0.001	<0.001	0.912
2	0.065	0.023	1620.7	2.842	<0.001	<0.001	0.895
3	0.182	0.027	1626.5	6.786	<0.001	<0.001	0.900
4	0.166	0.026	1624.4	6.347	<0.001	<0.001	0.893
5	0.094	0.018	1623.9	5.152	<0.001	<0.001	0.899
6	0.163	0.020	1621.1	8.002	<0.001	<0.001	0.904
7	0.011	0.015	1614.6	0.725	0.469	0.469	0.915

Note: regression models are

1. y  ~  cohort-age + within-person age change * drinking class + sex + ethnicity + SES + family history of AUD density + life trauma + (1|participant ID);

2. y  ~  within-person age change + cohort-age * drinking class + sex + ethnicity + SES + family history of AUD density + life trauma + (1|participant ID);

3. y  ~  within-person age change * cohort-age + drinking class + sex + ethnicity + SES + family history of AUD density + life trauma + (1|participant ID);

4. y  ~  within-person age change: cohort-age: drinking class + sex + ethnicity + SES + family history of AUD density + life trauma + (1|participant ID).

y is the mean cortical thickness of a pattern. β, fixed-effect regression coefficient; SD standard deviation, df degree of freedom; t, t value; p, uncorrected p value; q, FDR corrected p value. Adj. R2, adjusted R².