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Antiviral and cytotoxicity evaluation of the most promising SARS-CoV-2 Mpro inhibitors.
| Cmpd | Huh-7-ACE2 cells infected EC50 (μM) | Huh-7-ACE2 cells CC50 (μM) | SI |
|---|---|---|---|
| SPR38 | 18.5 ± 6.5 | 60.9 ± 11.5 | 3 |
| SPR39 | 1.5 ± 0.3 | 100 | 66.6 |
| SPR41 | 1.8 ± 0.1 | 14.5 ± 3.4 | 8 |
| Nirmatrelvir | <0.01 | >100 | >10.000 |
