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. 2022 Dec 1;13:1003975. doi: 10.3389/fimmu.2022.1003975

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Copyright © 2022 Kiss, Lebegge, Murgaski, Van Damme, Kancheva, Brughmans, Scheyltjens, Talebi, Awad, Elkrim, Bardet, Arnouk, Goyvaerts, Swinnen, Nana, Van Ginderachter and Laoui

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JAM-A does not affect myeloid cell diversification in the tumor microenvironment. (A) UMAP plot showing CD45⁺ immune cells from LLC tumors of both F11r ^flox/flox LysM-Cre^- and F11r ^flox/flox LysM-Cre⁺ mice color-coded by clusters defined based on single-cell RNA-seq data. (B) Heatmap showing the top 50 enriched genes in each myeloid cell cluster. The top 5 enriched genes per cluster are highlighted. See Supplementary Table 1 for list of top 50 enriched genes for all clusters shown in panel (A). (C) Heatmap showing F11r (encoding JAM-A) expression in tumors of F11r ^flox/flox LysM-Cre^- and F11r ^flox/flox LysM-Cre⁺ mice based on single-cell RNA-seq data. (D) UMAP plots showing CD45⁺ immune cells from LLC tumors of F11r ^flox/flox LysM-Cre^- or F11r ^flox/flox LysM-Cre⁺ mice color-coded by clusters shown in panel (A). (E) Number of differentially expressed (DE) genes (adjusted P value < 0.05, fold change (FC) > 2) between F11r ^flox/flox LysM-Cre⁺ and F11r ^flox/flox LysM-Cre^- mice within each myeloid cell cluster. See Supplementary Table 2 for full list of DE genes.