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. 2022 Dec 1;13:1060721. doi: 10.3389/fendo.2022.1060721

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Copyright © 2022 Lu, He, Zhang, Wang, Cheng, Lv, Yuan, Guo, You, Chen and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OB downregulated the catabolism in IL-1β–induced chondrocytes. Chondrocytes were administered with IL-1β (5 ng/ml) or/and OB (160 μM) for 24 h. (A) Western blot analysis and (B) quantitative data for the key catabolic-related proteins (MMP13, MMP3, and ADAMTS5). (C) Quantitative analysis of the catabolic-related (MMP13, MMP3, and ADAMTS5) mRNA expression by using RT-qPCR analysis. (D) Immunofluorescence staining and (E) quantitative data of the protein expression of MMP13. Data were presented as means ± SD (n = 3). ns, no significance; *p < 0.05; **p < 0.01; ***p < 0.001.