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. 2022 Dec 1;13:1060721. doi: 10.3389/fendo.2022.1060721

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Copyright © 2022 Lu, He, Zhang, Wang, Cheng, Lv, Yuan, Guo, You, Chen and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-1β triggered the early activation of PI3K/AKT/mTOR signaling pathway and OB inhibited the PI3K/AKT/mTOR signals in IL-1β–induced chondrocytes. (A) Western blot and (B) quantitative analysis for proteins associated with the PI3K/AKT/mTOR pathway in chondrocytes stimulated with 5 ng/ml IL-1β at different time durations (0, 0.25, 0.5, 1, and 2h). (C) Western blot analysis and (D) quantitative data the above proteins in chondrocytes which were administered with IL-1β (5 ng/ml) for 1 h or/and OB (160 μM) for 24 h. Data were presented as means ± SD (n = 3). ns, no significance; *p < 0.05; **p < 0.01; ***p < 0.001.