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. 2022 Dec 1;13:1060721. doi: 10.3389/fendo.2022.1060721

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Copyright © 2022 Lu, He, Zhang, Wang, Cheng, Lv, Yuan, Guo, You, Chen and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OB rescued the impaired autophagy process in IL-1β–induced chondrocytes. Chondrocytes were administered with IL-1β (5 ng/ml) or/and OB (160 μM) for 24 h. (A) Western blot and (B) quantitative analysis showed the impaired autophagy induced by IL-1β could be rescued by the treatment of OB (160 μM). (C) Chondrocytes were transfected with tandem GFP-RFP-LC3 adenovirus, and the strength of autophagic flux was captured with a confocal microscope. (D, E) Quantitative analysis of autolysomes (red puncta) and autophagosomes (yellow puncta) among groups. Data were presented as means ± SD (n = 3). ns, no significance; *p < 0.05; **p < 0.01; ***p < 0.001.