Table 3.

Z-score of genes identified by next generation RNA sequencing with the strongest downregulated and upregulated genes in non-responding patients and their affiliation with either cytoskeleton arrangement and actin remodeling or influencing osteoblast/osteoclast activity or differentiation.

Ensembl	Entrez	Symbol	Length	z-score						Cyto-skeletal/actin remodeling	Effect on bone cells
				Responder				Non-responder
				Patient ID #002H	Patient ID #005H	Patient ID #004H	Patient ID #001H	Patient ID #014H	Patient ID #013H
ENSG00000160949	4796	TONSL	7107	− 0.819	1.711	− 0.475	− 0.417	− 3.489	− 2.978	−	−
ENSG00000240583	358	AQP1	3436	− 1.635	0.796	0.008	0.832	− 2.352	− 1.428	+	+
ENSG00000164107	9464	HAND2	3601	− 1.366	1.219	− 0.491	0.639	− 2.070	− 2.112	+	+
ENSG00000013810	10460	TACC3	8202	− 1.388	0.589	− 0.440	1.238	− 1.763	− 2.513	+	−
ENSG00000099889	421	ARVCF	5636	− 0.213	1.260	0.431	− 1.477	− 1.726	− 2.699	+	−
ENSG00000141449	80000	GREB1L	10,572	− 1.653	0.274	0.342	1.037	− 1.584	− 1.402	−	−
ENSG00000092969	7042	TGFB2	6050	− 1.133	− 0.314	1.610	− 0.162	1.406	3.933	+	+
ENSG00000164176	10085	EDIL3	5825	− 1.107	− 0.527	1.580	0.054	1.465	2.919	−	+
ENSG00000125740	2354	FOSB	5553	− 1.076	− 0.537	0.014	1.598	1.607	2.044	−	+
ENSG00000229807	7503	XIST	25,266	− 0.175	− 0.754	1.683	− 0.754	1.654	1.716	−	+
ENSG00000144802	64332	NFKBIZ	5902	− 1.258	− 0.537	0.389	1.406	1.663	2.166	−	+
ENSG00000145681	1404	HAPLN1	6198	− 0.544	− 0.602	1.732	− 0.585	2.553	6.370	+	−
ENSG00000164619	168667	BMPER	7990	0.338	− 0.951	1.488	− 0.875	3.013	2.450	−	+
ENSG00000094963	2327	FMO2	6201	− 0.016	− 0.300	1.547	− 1.231	4.500	1.147	−	−
ENSG00000184557	9021	SOCS3	2734	− 0.709	− 0.806	− 0.164	1.679	4.572	1.205	+	+
ENSG00000112936	730	C7	6682	1.442	− 1.189	0.361	− 0.614	7.079	1.456	+	−

Genes marked in bold were chosen for RT-qPCR verification.